1200+ pathology MCQs with detailed explanations for FRCPath Part 1, Part 2, NEET-SS & NEET-PG, plus exam-specific strategy and study guidance.
These are from our published question bank — one high-yield question from each of ten organ systems and diagnostic themes. Try them now: click an option to see whether you're right and read the explanation. They're different from the four sampled on our free 199 MCQ PDF, so there's no overlap if you've already tried that page.
Tall cell carcinoma with reverse polarity (TCCRP) of the breast is associated with which mutation?
TCCRP is a rare subtype of breast carcinoma characterized by IDH2 mutations and papillary structures with reverse cellular polarity.
A 40-year-old woman with a family history of HNPCC presents with a signet ring adenocarcinoma in the transverse colon. Molecular analysis reveals MSI-H status, a germline mutation in MLH1, and a somatic mutation in TP53. What is the most likely underlying mechanism contributing to the development of this tumor?
MSI-H leads to susceptibility for multiple mutations. p53 is often the last mutation to occur in this pathway of colorectal carcinogenesis.
A 58-year-old male with a heavy smoking history presents with rapidly progressing dyspnea and a large mediastinal mass. Biopsy reveals poorly differentiated cells with abundant eosinophilic cytoplasm and eccentric nuclei. IHC shows loss of BRG1 expression. Most likely diagnosis?
Loss of BRG1 (encoded by SMARCA4) is diagnostic of SMARCA4-Deficient Undifferentiated Thoracic Tumor.
A 50-year-old male with 5 years of back pain has an MRI spine suggestive of multiple myeloma, an M spike of 2.4 g/dL, and no CRAB features. Bone marrow aspiration reveals 15% plasma cells. What is the diagnosis?
Smoldering multiple myeloma (SMM) is defined by serum M protein ≥3 g/dL and/or 10–60% clonal bone marrow plasma cells, with no CRAB criteria present.
A "basket-weave" appearance of the glomerular basement membrane on electron microscopy is indicative of:
Alport syndrome is inherited in an X-linked pattern and caused by COL4A5 gene mutations, producing the characteristic basket-weave GBM.
The presence of which chromosomal translocation is most commonly associated with high-grade endometrial stromal sarcoma (ESS) with YWHAE rearrangement?
The translocation t(10;17)(q22;p13) results in a YWHAE::NUTM2 gene fusion, frequently found in high-grade endometrial stromal sarcoma.
A 44-year-old woman presents with an itchy rash on extensor surfaces. What is the likely direct immunofluorescence (DIF) finding?
Dermatitis Herpetiformis (DH) reveals granular IgA deposits in the papillary dermis, classically presenting as an itchy rash on extensor surfaces.
Which metabolite accumulates as a result of IDH1 mutation?
2-hydroxyglutarate (2-HG) is an "oncometabolite" that accumulates with IDH mutations, central to gliomagenesis in IDH-mutant tumors.
What distinguishes high-risk HPV (16/18) from low-risk HPV (6/11) in pathogenesis regarding host DNA integration?
High-risk HPV integrates into host DNA, disrupting regulatory genes and causing unchecked overexpression of E6/E7 oncoproteins — the mechanism driving malignant transformation.
In an NHS pathology department, several breast carcinoma cases were incorrectly scored as HER2 negative due to non-participation in the external quality assessment (EQA) scheme. As a result, patients were denied HER2-targeted therapy. Which pillar of clinical governance is MOST directly breached in this scenario?
Non-participation in EQA schemes directly breaches the audit and clinical effectiveness pillar of clinical governance.
A unique visual approach to high-yield histopathology. This 81-page, 70-panel illustrated guide by Dr. Maitrayee Roy and Dr. Akshay Bali covers bone & soft tissue, dermatopathology, hematolymphoid, thoracic, gynecologic, genitourinary, renal, and gastrointestinal pathology — image-based and topic-wise, built for visual learners preparing for FRCPath Part 1, FRCPath Part 2, NEET-SS Pathology, and MD/DNB Pathology.
FRCPath and NEET SS test pathology MCQs differently. Here's what to expect from each, and how to prepare.
Both Part 1 and Part 2 use single-best-answer format, but the emphasis shifts. Part 1 tests general and systemic pathology fundamentals — disease mechanisms and pattern recognition in histopathology images. Part 2 raises the bar to advanced diagnostic scenarios: immunohistochemistry interpretation, subspecialty entities, and complex case-based reasoning. Strategy: build conceptual foundations for Part 1, then layer in image-heavy, scenario-based practice for Part 2. Explore the FRCPath Part 1 and FRCPath Part 2 courses.
NEET-SS and NEET-PG pathology MCQs integrate pathology with clinical medicine and recent diagnostic advances, with more emphasis on Indian disease patterns and epidemiology than FRCPath. Strategy: pair topic-wise practice with our NEET-SS notes and NEET-PG question bank — the two syllabi overlap heavily.
Five steps to get the most out of practice:
Take our diagnostic test to find your strengths and weaknesses, and prioritize your study plan.
Work through MCQs by topic — general pathology first, then systemic pathology.
Once comfortable, switch to timed sessions to build speed and exam-day efficiency.
Take full-length mock tests for realistic conditions and detailed performance analytics.
Revisit incorrect answers with spaced repetition to lock in weak areas for the long term.
Free downloads, courses, and practice tools in one place.
Normal tissue architecture — the foundation for accurate histopathology interpretation.
Learn MoreVideo lectures, notes, and mock tests for FRCPath Part 1 success.
Explore CourseFull-length mock exams simulating real FRCPath conditions with performance analysis.
Take Mock TestGoogle Books listings for our published MCQ book and comic book will be added here once the live URLs are confirmed.
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